Thalassemia Major is a most severe form of beta thalassemia. It develops when beta globin genes are missing. Frequently there is gentle to serious iron deficiency (low red platelets). Iron deficiency can bring about inclination drained and fair skin. There may likewise be bone issues, enlarged spleen, pale or yellowish skin, facial bone deformities, abdominal swelling, slow growth, dark urine, and among youngster’s moderate development. Thalassemia are hereditary disarranges acquired from an individual's families. There are two primary categories, Thalassemia Minor and Thalassemia Major. The seriousness of Thalassemia Minor and Thalassemia Major relies upon what number of the four qualities for alpha globin or two qualities for beta globin are absent.