Acromegaly is a disease that consequences from excess increase hormone (GH) after the boom plates have closed. The preliminary symptom is typically expansion of the hands and feet. There may also be growth of the forehead, jaw, and nose. Other signs and symptoms may encompass joint pain, thicker skin, deepening of the voice, headaches, and troubles with vision. Complications of the disorder may include type 2 diabetes, sleep apnoea, and excessive blood pressure. Acromegaly is typically due to the pituitary gland producing too much growth hormone. In greater than 95% of cases the excess production is due to a benign tumour, known as a pituitary adenoma. Symptoms may encompass Enlarged fingers and feet, Coarsened, enlarged facial features, Coarse, oily, thickened pores and skin, Excessive sweating and body odour, Small outgrowths of pores and skin tissue, Fatigue, and muscle weakness.

Addison's disease, also called primary adrenal insufficiency and hypercortisolism, is a long-term endocrine disorder in which the adrenal glands do no longer produce enough steroid hormones. Symptoms normally come on slowly and can also include stomach pain, weakness, and weight loss. Darkening of the skin in certain areas can also arise. Under certain circumstances, rise with low blood pressure, vomiting and loss of consciousness. An adrenal crisis may be induced by way of stress, along with from an injury, surgery, or infection. Symptoms consists of ack of power or motivation (fatigue), muscle weakness, low mood, loss of appetite and accidental weight loss, improved thirst.